Anti-inflammatory Steroidal Alkaloids from Sarcococca wallichii of Nepalese Origin

New cholinesterase inhibiting steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.

From the leaves of Sarcococca coriacea two new steroidal alkaloids, epoxynepapakistamine-A [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-16alpha,17alpha-epoxy-2beta,4beta-di-O-acetate] (1), and epoxysarcovagenine-D [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-2-en-16alpha,17alpha-epoxy-4-one] (2), and two known compounds funtumafrine C [(20S)-20-(N,N-dimethylamino...

Steroidal alkaloids from Veratrum taliense

Phytochemical reinvestigation of the roots and rhizomes of Veratrum taliense yield three known (solanidine, veramiline-3-0-~D-glucopyranoside and stenophylline B-3-0-~D-glucopyranoside) and two novel steroidal alkaloids. The structures of the new compounds have been established by a combination of spectroscopic methods as 3angeloylzygadenine-I3-N-oxide and (20S,25S)-22,26-epiminocholesta-5,22-d...

Non-steroidal anti-inflammatory drugs.

Anti-inflammatory alkaloids from the stems of Picrasma quassioides BENNET.

During further chemical and biological investigations of Picrasma quassioides BENNET, four new bis-β-carboline alkaloids, quassidines E-H (1-4), and three new β-carboline alkaloids, canthin-16-one-14-butyric acid (5), 3-(1,1-dimethoxylmethyl)-β-carboline (6), and 6,12-dimethoxy-3-formyl-β-carboline (7), were isolated from its anti-inflammatory CHCl(3)-soluble fraction. Structures of new compoun...

Safety of non-steroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in medical practice for treating pain, inflammation and degenerative joint diseases (for instance, arthritis). The use of traditional NSAIDs (tNSAIDs), however, is associated with an increased risk of minor and serious gastrointestinal (GI) events. It is estimated that in the European Union thousands of gastrointestinal complication...